Research in the TKCC is enabled by Telethon Kids resources, including the Bioinformatics facility, Flow Cytometry facility, Microscopy and Histology facility, Bioresources Centre, radiation and imaging facilities and Tissue Bank.
Flow Cytometry and Cell Sorting. This facility provides researchers with access to state-of-the-art equipment and expertise that enables isolation, separation and analysis of cell populations based on their biological and therapeutic properties. The facility offers multi-parameter flow cytometric analysis for identifying rare populations of cells within complex mixtures such as bone marrow, and a fully supported fluorescent activated cell sorting (FACS) instrument for isolating specific cells under sterile conditions. Find out more.
Bright Blue Cancer Analysis Suite. This facility generously supported by a donation from Bright Blue provides sophisticated histology and microscopy equipment and analysis software to facilitate laboratory research integral to a wide range of cancer research projects. The suite houses worldclass equipment encompassing all aspects of tissue processing for histology and pathology and enables a wide range of microscopy such as live cell imaging, immunofluorescence, confocal microscopy, multispectral and brightfield imaging. Find out more.
Bioresources Centre. We maintain animal models representing multiple different strains of transgenic and gene-targeted mice. Telethon Kids Institute Animal Ethics Committee (AEC) has an important role in overseeing the ethical conduct of any work involving the use of animals for scientific purposes, conforming to the NHMRC Australian Code for the Care and Use of Animals for Scientific Purposes.
Preclinical imaging and therapeutics. A generous donation by the Telethon Adventurers in 2010 enabled the purchase and installation of the first multi-spectral live animal imaging machine in Western Australia. This IVIS Spectrum (named Elliot's Machine after a Perth boy who died from medulloblastoma) is one of only 5 in the country and allows our cancer researchers to detect and track cancer growth in laboratory models of cancer. TKCC researchers recently obtained funding in excess of $800,000 to purchase and install a small animal radiation machine which is the first of its kind in Australia. This X-RAD 225Cx uses CT imaging to precisely target radiation to rodent models of cancer, monitored in real-time, mimicking the capabilities of modern human radiation therapy instruments. Our radiation therapy research aims to successfully translate preclinical discoveries into clinical practice to improve cancer treatment in Australia and globally.
Tissue Bank. Researchers at Princess Margaret Hospital and Telethon Kids have been collecting and annotating paediatric cancer samples for over 30 years. This tissue bank provides researchers with ethically collected, high quality human cancer tissue, blood and de-identified clinical data for our investigative projects; it also supports clinical trials at PMH by storing blood and tissue specimens.
The McCusker Charitable Foundation Bioinformatics Centre. The Bioinformatics facility at Telethon Kids processes the huge volumes of molecular data produced by the labs of TKCC. They provide support and expertise in open-source software, as well as custom-made computational algorithms, analysis pipelines and web interfaces designed specifically for cancer research. Find out more.