Australian Study of Causes of Acute Lymphoblastic Leukaemia in Children
TKI Investigators: Elizabeth Milne, Carol Bower, Nick de Klerk, Ursula Kees, External collaborators: Bruce Armstrong, Frank van Bockxmeer, Michelle Haber, Rodney Scott, John Attia, Murray Norris, Lin Fritschi, Margaret Miller, Judith Thompson, Frank Alvaro, Catherine Cole, Luciano Dalla Pozza, John Daubenton, Peter Downie, Marie Kirby, Liane Lockwood, Glenn Marshall, Elizabeth Smibert, Ram Suppiah .
Researchers in the Childhood Cancer Epidemiology program have continued analysing data collected between 2003 and 2007 in this national case-control study of the risk factors for childhood acute lymphoblastic leukaemia (ALL). The study recruited children with ALL and their parents from the nine paediatric oncology units nationwide, together with control children from around Australia. DNA samples were collected and parents were surveyed about a wide range of exposures.
Funders of the project: NHMRC Grant #254539, and Cancer Council WA.
The following papers using data from this study were published in 2015:
Bailey HD, Metayer C, MilneE, et al. Home paint exposures and risk of childhood acute lymphoblastic leukemia: Findings from the Childhood Leukemia International Consortium. Cancer Causes and Control, 2015: 26(9);1257-1270
Bailey HD, Infante-Rivard C, Metayer C, Clavel J, Lightfoot T, Kaatsch P, Roman E, Magnani C, Spector LG, Petridou E, MilneE et al. Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium. International Journal of Cancer, 2015:137(11); 2644-2663
Paltiel O, Tikellis G, Linet L, Golding J, Lemeshow S, Phillips G, Lamb K, Stoltenberg C, Håberg SE, Strőm M, Granstrőm C, Northstone K, Klebanoff M, Ponsonby A-L, Milne E et al. Birthweight and childhood cancer: preliminary findings from the International Childhood Cancer Cohort Consortium (I4C). Paediatric and Perinatal Epidemiology 2015:29(4); 335-345.
Greenop KR, Bailey HD, Miller M, Scott RJ, Attia J, Ashton LJ, Downie P, Armstrong BK, Milne E. Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. Nutrition & Cancer. 2015:67:3, 431-441, DOI: 10.1080/01635581.2015.998839
Rudant, J, Lightfoot T, Urayama K, Petridou E, Dockerty JD, Magnani C, Milne E, et al. Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium Study. American Journal of Epidemiology 2015. 181(8):549-62. doi: 10.1093/aje/kwu298. Epub 2015 Mar 1.
Dawson S, Charles AK, Bower C, de Klerk NH, Milne E. Risk of cancer among children with birth defects: a novel approach. Birth Defects Research Part A. 2015;103:283-290. Doi: 10.1002/bdra.23364
Milne E, Greenop KR, Scott RJ, Haber M, Norris MD, Attia J, Jamieson SE, Miller M, Bower C, Bailey HD, Dawson S, McGowage GB, de Klerk NH, van Bockxmeer FM, Armstrong BK Folate pathway gene polymorphisms, maternal folic acid use and risk of childhood acute lymphoblastic leukemia. Cancer Epidemiology, Biomarkers and Prevention 2015;24(1): 48-56
National Case-Control Study of Childhood Brain Tumours
TKI Investigators: Elizabeth Milne, Carol Bower, Nick de Klerk, Peter Dallas Collaborators: Bruce Armstrong, Frank van Bockxmeer, Rodney Scott, John Attia, Lin Fritschi, David Ashley, Lesley Ashton, Judith Thompson, Murray Norris , Richard Cohn, Margaret Miller, Luce dalla Pozza, John Daubenton, Timothy Hassall, Maria Kirby, Stewart Kellie, Ross Pinkerton, Frank Alvaro, Angela Alessandri.
The Australian Study of Childhood Brain Tumours was a national case-control study into the risk factors for childhood brain tumours (CBT). It aimed to investigate genetic, dietary and environmental risk factors for CBT. The study recruited case and control families between 2006 and 2010; data collection was completed in 2011. The study involved children aged 0-14 years. Case children and their parents were recruited from the nine paediatric oncology units nationwide.
Funders of the project: NHMRC Grant #404089.
The following papers were published in 2015:
Greenop KR, Miller M, Bailey HD, Scott RJ, Attia J, Bower C, van Bockxmeer FM, Ashton LJ, Armstrong BK, Milne E. Paternal dietary folate, B6 and B12 intake and the risk of childhood brain tumors. Nutrition & Cancer. 2015:67(2) 224-230.
Greenop KR, Scott RJ, Attia J, Bower C, de Klerk NH, Norris MD, Haber M, Jamieson SJ, van Bockxmeer FM, Gottardo NG, Ashton LJ, Armstrong BK, Milne E. Folate pathway gene polymorphisms and risk of childhood brain tumors: results from an Australian case-control study. Cancer Epidemiology, Biomarkers and Prevention. 2015: 24(6); 1-7.
Greenop KR, Miller M, Bailey HD, de Klerk NH, Attia J, Kellie SJ, Bower C, Armstrong BK, Milne E. Childhood folate, B6, B12 and food group intake and the risk of childhood brain tumors: results from an Australian case-control study. Cancer Causes and Control. 2015: 26:871-879. doi:10.1007/s10552-015-0562-z
Greenop KR, Hinwood A, Fritschi L, Scott RJ, Attia J, Ashton LJ, Heath J, Armstrong BK, Milne E. Vehicle refuelling, use of domestic wood heaters and the risk of childhood brain tumors: results from an Australian case-control study. Pediatric Blood & Cancer 2015;62:229-234 DOI: 10.1002/pbc.25268.
Nutrition and Genome Health in Children
TKI Investigators: Elizabeth Milne, Nick de Klerk Collaborators: Michael Fenech, Bruce Armstrong, Margaret Miller, Nathan O'Callaghan
The Nutrition and Genome Health in Children Study aimed to identify key nutritional and genetic factors associated with DNA damage in children. It aimed to describe the nature of the interaction between nutritional and genetic factors in determining level of DNA damage in children, and also the associations between body mass index, DNA damage and micronutrient levels in children.
This study was a cross-sectional study of 450 Western Australian children, conducted between 2009 and 2011. Participants were children aged 3, 6 or 9 years at recruitment who had never been diagnosed with asthma, diabetes, cancer, arthritis or epilepsy. Participants and their parents were recruited via primary schools, posters displays and flyers, advertisements in local newspapers and information letters distributed to a wide range of organizations. These include crèches, day care centres, playgroups, sports centres and libraries. The child's diet and macro- and micro-nutrient intake was assessed using parent-completed Food Frequency Questionnaires (FFQs). A sample of the child's blood was taken and used to assess micronutrient levels and specific biomarkers of DNA damage. The blood sample was also used to identify genetic polymorphisms related to nutrient metabolism and DNA repair. Saliva samples collected from the child were used to measure cortisol and cotinine levels, as indicators of psychological stress and exposure to environmental tobacco smoke, respectively. Parents were given feedback on their child's diet, and dietary advice was provided by a dietitian where needed. In all, 464 participants provided data.
Funders of the project: NHMRC Grant#572623.
The following papers were published in 2015
Milne E, Greenop KR, Ramankutty P, Miller M, de Klerk NH, Armstrong BK, Almond T, O'Callaghan N, Fenech M. Blood micronutrients and DNA damage in children. Molecular Nutrition and Food Research, 2015:59(10); 2057-2065.
Milne E, O'Callaghan N, Ramankutty P, de Klerk NH, Greenop KR, Armstrong BK, Miller M, Fenech M. Plasma micronutrient levels and telomere length in children. Nutrition 2015; 31(2):331-6
Prenatal origins and health outcomes of male reproductive congenital anomalies diagnosed at birth and testicular cancer in adulthood
TKI Investigators: Elizabeth Milne Collaborators: Natasha Nassar, Gavin Pereira
This study involves record linkage of birth, birth defects, hospital, deaths and cancer data; with links to genealogy data to identify links between families. It will include the analysis of NSW and Western Australia (WA) population health data. The AIMS of the study are to:
Identify antecedents of male reproductive congenital anomalies (hypospadias and cryptorchidism) and testicular cancer; including maternal and prenatal factors, familial aggregation and their combined role
Identify antecedents of testicular cancer; including maternal, prenatal and familial factors and taking into account intermediary effects of hypospadias and cryptorchidism
Describe the health outcomes and subsequent fertility (births) among males previously diagnosed with reproductive congenital anomalies or testicular cancer
The data have not yet been received from the WA Data Linkage Branch.
Funders of the project: NHMRC Grant# ID: APP1047263