Research projects
Childhood Cancer Immunotherapy Program
New Childhood Brain Cancer Research
37 Years of Dedication
Introducing the Telethon Kids Cancer Centre
Unlocking the key to leukaemia progression in kids
The new sarcoma research team
Meet Finlay
The SJ Elliot Cancer Trial
Latest publications
Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma
Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular mechanisms that lead to chemoresistance traits of ST-RELA remain elusive. The aim of this study was to assess RELA fusion-dependent signaling modules, specifically the role of the Hedgehog (Hh) pathway as a novel targetable vulnerability in ST-RELA.
Children's Cancers Published research Brain Tumour ResearchAcute Lymphoblastic Leukemia in Infants: A Distinctive, High-Risk Subtype of Childhood Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) in infants younger than 1 year of age is an aggressive, high-risk subtype of childhood ALL. Infant ALL with KMT2A-r is characteristically poorly responsive to chemotherapy and hematopoietic stem cell transplantation. New strategies, such as molecularly targeted therapies and immunotherapies, are in development and show promise in preclinical models and early phase studies.
Children's Cancers Published research Leukaemia Translational ResearchLessons learnt from influenza vaccination in immunocompromised children undergoing treatment for cancer
Influenza infection contributes substantially to global morbidity and mortality, with children undergoing treatment for cancer among the most vulnerable due to immunosuppression associated with disease and treatment. However, influenza remains one of the most common vaccine-preventable diseases.
Children's Cancers Published research Immunisation Influenza Leukaemia Translational Research