Research projects
Childhood Cancer Immunotherapy Program
New Childhood Brain Cancer Research
37 Years of Dedication
Introducing the Telethon Kids Cancer Centre
Unlocking the key to leukaemia progression in kids
The new sarcoma research team
Meet Finlay
The SJ Elliot Cancer Trial
Latest publications
Insights into the Clinical, Biological and Therapeutic Impact of Copy Number Alteration in Cancer
Copy number alterations (CNAs), resulting from the gain or loss of genetic material from as little as 50 base pairs or as big as entire chromosome(s), have been associated with many congenital diseases, de novo syndromes and cancer. It is established that CNAs disturb the dosage of genomic regions including enhancers/promoters, long non-coding RNA and gene(s) among others, ultimately leading to an altered balance of key cellular functions.
Children's Cancers Published research Leukaemia Translational Research Translational Genomics in LeukaemiaTowards precision cancer medicine for Aboriginal and Torres Strait Islander cancer health equity
Delivering cancer control at scale for Aboriginal and Torres Strait Islander communities is a national priority that requires Aboriginal and Torres Strait Islander leadership and codesign, as well as significant involvement of the Aboriginal community-controlled health sector. The unique genomic variation observed among Aboriginal and Torres Strait Islander peoples may have implications for standard and precision medicine.
Children's Cancers Published research Aboriginal Health Brain Tumour Research Indigenous Genomics Cancers (other)The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program
Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled ETO2 depletion models. We demonstrate that beyond its well-established repressive activity, ETO2 directly activates transcription of MYB, among other genes.
Children's Cancers Published research Translational Genomics in LeukaemiaChildhood Cancer Incidence and Survival in South Australia and the Northern Territory, 1990–2017, with Emphasis on Indigenous Peoples
Reports of a rise in childhood cancer incidence in Australia and globally prompted the investigation of cancer incidence and survival in South Australia and the Northern Territory over a 28-year period, with emphasis on Indigenous peoples.
Children's Cancers Published research Aboriginal Health Indigenous Genomics