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        Research

        Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103− and XCR1+CD103+ dendritic cells

        This report provides new insight into the functional specialization within the broad network of dendritic cells that are responsible for skin immunosurveillance ...

        Research

        Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape.

        This article summarizes data from collaborative group and institutional trials that have advanced the science of pediatric brain tumors. ...

        Research

        The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision.

        This article investigates the impact of burn & excisional injury on the immune system. ...

        Research

        Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors

        Acute lymphoblastic leukemia and childhood brain tumors are 2 of the most common forms of childhood cancer, but little is known of their etiology. ...

        Research

        Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.

        This study describes the development and molecular characterization of a panel of patient-derived infant leukemia oncogene xenografts and their sensitivity... ...

        Research

        Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors

        We found no evidence of positive associations between risk of childhood brain tumours overall and childhood or parental pre-pregnancy radiological procedures. ...

        Research

        The Childhood Leukemia International Consortium

        The Childhood Leukemia International Consortium (CLIC) was established in 2007 to promote investigations of rarer exposures, gene-environment interactions... ...

        Research

        Parental smoking and risk of childhood brain tumors

        Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. ...

        Research

        Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors

        Childhood acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and brain tumors (CBTs) are the leading cause of cancer death in... ...

        Research

        MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63

        We hypothesized that reactivation of p53 by inhibition of its negative regulator will result in p53-mediated growth arrest and apoptosis. ...

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